The Disturbance of the Oxidants-Antioxidants Balance in Epileptic Children
Authors: Barbara Artemowicz, Elżbieta Sołowiej, Wojciech Sobaniec
Received 8 March 2004; accepted 25 August 2004
Correspondance and requests for reprints should be addressed to:
Barbara Artemowicz
Department of Paediatric Neurology and Rehabilitation
Medical University of Białystok
17 Waszyngtona Str.
15-274 Białystok,
Poland
Abstract
Introduction
Oxidative injury is an important factor in development many of acute an chronic diseases of the central nervous system. Epilepsy is one of these diseases. Free radical generation in the brain can induce seizure activity and initiate neurodegenerative processes. The activity of endogenous antioxidants in the brain is lower in comparison to other tissues.
Objectives
We have studied the antioxidative enzymes (superoxide dismutase SOD, glutathione peroxidase GSH-Px and glutathione reductase GSSG-R) activity and lipid peroxidation processes as malondialdehyde (MDA) concentration in serum of epileptic children and influence of antiepileptic drugs on these.
Methodology
Serum concentrations were measured in a robust sample of long-term and newly diagnosed epileptic children.
Results
We observed significant decreases of SOD and GSSG-R activity and significant increases of MDA concentration in children with symptomatic and long-term treated epilepsy. The activity of GSH-Px was not significantly changed. Moreover, SOD activity was significantly decreased in children treated monotherapy with carbamazepine (CBZ) and polytherapy, GSH-Px activity was significantly decreased only in polytherapy and GSSG-R was not significantly changed by antiepileptic therapy. MDA concentration was significantly decreased in serum from children treated with val (VPA) as monotherapy or combination therapy.
Conclusions
The results indicate that the oxidants- antioxidants balance in the serum of epileptic children is disturbed and is modified by antiepileptic medication.
Key Words
Oxidant-antioxidant-lipid peroxidation-epilepsy-children
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