Exploring the Neuropathological Correlates of Chronic Traumatic Encephalopathy in Post-Mortem Brain Tissue from Former Athletes.

Dr. Simran Singh, Associate Professor, Department of Neurology, NBRC, Haryana

Abstract: 

Chronic Traumatic Encephalopathy (CTE) is a progressive neurodegenerative tauopathy linked to repetitive head impacts, commonly observed in former athletes. While clinical symptoms are diverse, ranging from mood and behavioral changes to cognitive decline and dementia, definitive diagnosis remains exclusively post-mortem through neuropathological examination. This research aims to comprehensively characterize the neuropathological hallmarks of CTE in a cohort of former athletes, utilizing advanced immunohistochemical techniques on post-mortem brain tissue. We will specifically investigate the distribution and severity of hyperphosphorylated tau (p-tau) protein aggregates, a pathognomonic feature of CTE, focusing on their perivascular accumulation at the depths of cortical sulci. Additionally, we will assess for co-occurring pathologies such as TDP-43 proteinopathy and amyloid-beta deposition to understand their contribution to the overall disease presentation. By correlating these microscopic findings with available clinical histories and durations of athletic exposure, this study seeks to further elucidate the complex interplay between repetitive head trauma and neurodegeneration, ultimately contributing to a more nuanced understanding of CTE's pathogenesis and informing future diagnostic and therapeutic strategies.

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